Food-drugs interactions

The “food-drug interactions” demonstrator

Exploring centralised information for potential food-drug interactions

Food and health are intimately related. In this regard, consumption of foods containing bioactive compounds, which have a role in reduced risk of non-communicable diseases (e.g., cancer, cardiovascular disease), has increased with the aim of maintaining health or preventing disease. Coupled with an ageing and poly-medicated European population, this raises concerns around the potential for interactions between foods and medicines.

However, current knowledge about these reactions in clinical practice is reported to be unsatisfactory. Therefore, tools to exploit the vast body of literature describing food-drug interactions are needed to support a range user communities (e.g., clinicians, dietitians) in understand more about the risks associated with food-drug interactions as well as future research (e.g., nutriomics researchers, bioinformaticians. The FooDrugs web tool was developed in the FNS-cloud project for user communities interested in potential food-drug interactions (FDIs). It is a bioinformatic tool that centralises information from different text documents and gene expression data on potential FDIs.

To demonstrate the utility of open access data for data reuse, we compiled a new dataset of potential FDIs based on available resources. To acheive this, we developed new analytical frameworks to extract food information from scientific documents. Then we created an open access and user-friendly resource to centralise information about potential FDIs, which was lacking in the field. The FooDrugs database and online platform were born! Learn more about these resources below. 👇👇👇

Target audience

FooDrugs is designed for clinicians, nutritionists and researchers working with bioactives, food supplements and personalised nutrition.

Related publications:
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Use cases:

Three use cases were developed to demonstrate how to use the tool:

  1. How to explore potential food-drug interactions in text documents from the FooDrugs database
  2. How to explore information on similar gene signatures between foods and drugs
  3. How to access information for the food transcriptomic studies and gene expression profiles stored in FooDrugs database

The three video tutorials demonstrating these use cases are available on the help page of the tool.

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